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Membrane targeting and activation of the Lowe syndrome protein OCRL1 by rab GTPases
The X-linked disorder oculocerebrorenal syndrome of Lowe is caused by mutation of the OCRL1 protein, an inositol polyphosphate 5-phosphatase. OCRL1 is localised to the Golgi apparatus and early endosomes, and can translocate to lamellipodia upon growth factor stimulation. We show here that OCRL1 int...
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| Hauptverfasser: | , , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2006
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1553191/ https://ncbi.nlm.nih.gov/pubmed/16902405 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7601274 |
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