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The role of the hypervariable C-terminal domain in Rab GTPases membrane targeting

Intracellular membrane trafficking requires correct and specific localization of Rab GTPases. The hypervariable C-terminal domain (HVD) of Rabs is posttranslationally modified by isoprenyl moieties that enable membrane association. A model asserting HVD-directed targeting has been contested in previ...

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Autores principales: Li, Fu, Yi, Long, Zhao, Lei, Itzen, Aymelt, Goody, Roger S., Wu, Yao-Wen
Formato: Artigo
Lenguaje:Inglês
Publicado: National Academy of Sciences 2014
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3932868/
https://ncbi.nlm.nih.gov/pubmed/24550285
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1313655111
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