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Loss of Oncogenic H-ras-Induced Cell Cycle Arrest and p38 Mitogen-Activated Protein Kinase Activation by Disruption of Gadd45a
The activation of p53 is a guardian mechanism to protect primary cells from malignant transformation; however, the details of the activation of p53 by oncogenic stress are still incomplete. In this report we show that in Gadd45a(−/−) mouse embryo fibroblasts (MEF), overexpression of H-ras activates...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Microbiology
2003
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC155214/ https://ncbi.nlm.nih.gov/pubmed/12748288 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.23.11.3859-3871.2003 |
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