Loss of Oncogenic H-ras-Induced Cell Cycle Arrest and p38 Mitogen-Activated Protein Kinase Activation by Disruption of Gadd45a

The activation of p53 is a guardian mechanism to protect primary cells from malignant transformation; however, the details of the activation of p53 by oncogenic stress are still incomplete. In this report we show that in Gadd45a(−/−) mouse embryo fibroblasts (MEF), overexpression of H-ras activates...

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Hlavní autoři: Bulavin, Dmitry V., Kovalsky, Oleg, Hollander, M. Christine, Fornace Jr., Albert J.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2003
Témata:
Cell Growth and Development
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC155214/
https://ncbi.nlm.nih.gov/pubmed/12748288
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.23.11.3859-3871.2003
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