Relating TCR-peptide-MHC affinity to immunogenicity for the design of tumor vaccines

One approach to enhancing the T cell response to tumors is vaccination with mimotopes, mimics of tumor epitopes. While mimotopes can stimulate proliferation of T cells that recognize tumor-associated antigens (TAAs), this expansion does not always correlate with control of tumor growth. We hypothesi...

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Main Authors: McMahan, Rachel H., McWilliams, Jennifer A., Jordan, Kimberly R., Dow, Steven W., Wilson, Darcy B., Slansky, Jill E.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Clinical Investigation 2006
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1551931/
https://ncbi.nlm.nih.gov/pubmed/16932807
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI26936
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