Mutation of Pten/Mmac1 in mice causes neoplasia in multiple organ systems

Pten/Mmac1+/− heterozygous mice exhibited neoplasms in multiple organs including the endometrium, liver, prostate, gastrointestinal tract, thyroid, and thymus. Loss of the wild-type allele was detected in neoplasms of the thymus and liver. Surprisingly, tumors of the gastrointestinal epithelium deve...

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Veröffentlicht in:	Proc Natl Acad Sci U S A
Hauptverfasser:	Podsypanina, Katrina, Ellenson, Lora Hedrick, Nemes, Adriana, Gu, Jianguo, Tamura, Masahito, Yamada, Kenneth M., Cordon-Cardo, Carlos, Catoretti, Giorgio, Fisher, Peter E., Parsons, Ramon
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	National Academy of Sciences 1999
Schlagworte:	Biological Sciences
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC15517/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9990064/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.96.4.1563
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