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Glycoprotein I of Varicella-Zoster Virus Is Required for Viral Replication in Skin and T Cells

Varicella-zoster virus (VZV) glycoprotein I (gI) is dispensable in cell culture; the SCIDhu model of VZV pathogenesis was used to determine whether gI is necessary in vivo. The parental and repaired viruses grew in human skin and thymus/liver implants, but the gI deletion mutant was not infectious....

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Udgivet i:J Virol
Principais autores: Moffat, Jennifer, Ito, Hideki, Sommer, Marvin, Taylor, Shannon, Arvin, Ann M.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology (ASM) 2002
Fag:
Pathogenesis and Immunity
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC155157/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12134050/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/JVI.76.16.8468-8471.2002
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