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Attenuation of the Vaccine Oka Strain of Varicella-Zoster Virus and Role of Glycoprotein C in Alphaherpesvirus Virulence Demonstrated in the SCID-hu Mouse

The SCID-hu mouse implanted with human fetal tissue is a novel model for investigating human viral pathogenesis. Infection of human skin implants was used to investigate the basis for the clinical attenuation of the varicella-zoster virus (VZV) strain, V-Oka, from which the newly licensed vaccine is...

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Bibliographic Details
Main Authors: Moffat, Jennifer F., Zerboni, Leigh, Kinchington, Paul R., Grose, Charles, Kaneshima, Hideto, Arvin, Ann M.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 1998
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC124567/
https://ncbi.nlm.nih.gov/pubmed/9444989
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