Cre Levels Limit Packaging Signal Excision Efficiency in the Cre/loxP Helper-Dependent Adenoviral Vector System

Helper-dependent (HD) adenovirus vectors devoid of all viral coding sequences have a large cloning capacity and provide long-term transgene expression in vivo with negligible toxicity, making them attractive vectors for gene therapy. Currently, the most efficient means of producing HD vectors involv...

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Bibliografiske detaljer
Main Authors: Ng, Philip, Evelegh, Carole, Cummings, Derek, Graham, Frank L.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2002
Fag:
Gene Therapy
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC155107/
https://ncbi.nlm.nih.gov/pubmed/11932383
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.76.9.4181-4189.2002
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