Targeted inhibition of p38 MAPK promotes hypertrophic cardiomyopathy through upregulation of calcineurin-NFAT signaling

The MAPKs are important transducers of growth and stress stimuli in virtually all eukaryotic cell types. In the mammalian heart, MAPK signaling pathways have been hypothesized to regulate myocyte growth in response to developmental signals or physiologic and pathologic stimuli. Here we generated car...

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Main Authors: Braz, Julian C., Bueno, Orlando F., Liang, Qiangrong, Wilkins, Benjamin J., Dai, Yan-Shan, Parsons, Stephanie, Braunwart, Joseph, Glascock, Betty J., Klevitsky, Raisa, Kimball, Thomas F., Hewett, Timothy E., Molkentin, Jeffery D.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Clinical Investigation 2003
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC155046/
https://ncbi.nlm.nih.gov/pubmed/12750397
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI200317295
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