Targeted inhibition of p38 MAPK promotes hypertrophic cardiomyopathy through upregulation of calcineurin-NFAT signaling

The MAPKs are important transducers of growth and stress stimuli in virtually all eukaryotic cell types. In the mammalian heart, MAPK signaling pathways have been hypothesized to regulate myocyte growth in response to developmental signals or physiologic and pathologic stimuli. Here we generated car...

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Bibliografiske detaljer
Main Authors: Braz, Julian C., Bueno, Orlando F., Liang, Qiangrong, Wilkins, Benjamin J., Dai, Yan-Shan, Parsons, Stephanie, Braunwart, Joseph, Glascock, Betty J., Klevitsky, Raisa, Kimball, Thomas F., Hewett, Timothy E., Molkentin, Jeffery D.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Clinical Investigation 2003
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC155046/
https://ncbi.nlm.nih.gov/pubmed/12750397
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI200317295
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