Phosphorylation of presenilin-2 regulates its cleavage by caspases and retards progression of apoptosis
Mutations within the Presenilin-2 (PS-2) gene are associated with early onset familial Alzheimer’s disease. The gene encodes a polytopic transmembrane protein that undergoes endoproteolytic processing resulting in the generation of N-terminal and C-terminal fragments (CTFs). PS-2 is also cleaved by...
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| Publicado no: | Proc Natl Acad Sci U S A |
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| Principais autores: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
1999
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC15473/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9990034/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.96.4.1391 |
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