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Presenilin, Notch, and the genesis and treatment of Alzheimer's disease
Elucidation of the proteolytic processing of the amyloid β-protein precursor (APP) has revealed that one of the two proteases (γ-secretase) that cleave APP to release amyloid β-protein (Aβ) is likely to be presenilin. Presenilin also mediates the γ-secretase-like cleavage of Notch receptors to enabl...
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| Formato: | Artigo |
| Lenguaje: | Inglês |
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The National Academy of Sciences
2001
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| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC58679/ https://ncbi.nlm.nih.gov/pubmed/11572965 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.211352598 |
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