Presenilin, Notch, and the genesis and treatment of Alzheimer's disease
Elucidation of the proteolytic processing of the amyloid β-protein precursor (APP) has revealed that one of the two proteases (γ-secretase) that cleave APP to release amyloid β-protein (Aβ) is likely to be presenilin. Presenilin also mediates the γ-secretase-like cleavage of Notch receptors to enabl...
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| Publicado no: | Proc Natl Acad Sci U S A |
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| Autor principal: | |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2001
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC58679/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11572965/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.211352598 |
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