Phosphorylation of presenilin-2 regulates its cleavage by caspases and retards progression of apoptosis

Mutations within the Presenilin-2 (PS-2) gene are associated with early onset familial Alzheimer’s disease. The gene encodes a polytopic transmembrane protein that undergoes endoproteolytic processing resulting in the generation of N-terminal and C-terminal fragments (CTFs). PS-2 is also cleaved by...

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Bibliografische gegevens

Gepubliceerd in:	Proc Natl Acad Sci U S A
Hoofdauteurs:	Walter, Jochen, Schindzielorz, Alice, Grünberg, Jürgen, Haass, Christian
Formaat:	Artigo
Taal:	Inglês
Gepubliceerd in:	National Academy of Sciences 1999
Onderwerpen:	Biological Sciences
Online toegang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC15473/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9990034/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.96.4.1391
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