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Optimization of Single-Base-Pair Mismatch Discrimination in Oligonucleotide Microarrays
The discrimination between perfect-match and single-base-pair-mismatched nucleic acid duplexes was investigated by using oligonucleotide DNA microarrays and nonequilibrium dissociation rates (melting profiles). DNA and RNA versions of two synthetic targets corresponding to the 16S rRNA sequences of...
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| Main Authors: | , , , , , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
American Society for Microbiology
2003
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC154504/ https://ncbi.nlm.nih.gov/pubmed/12732557 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AEM.69.5.2848-2856.2003 |
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