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The VHL protein recruits a novel KRAB-A domain protein to repress HIF-1α transcriptional activity
The von Hippel-Lindau tumor suppressor (pVHL) is a component of an E3 ubiquitin ligase and targets hypoxia-inducible factor-1α (HIF-1α) for ubiquitylation and degradation under normoxic conditions. pVHL also directly inhibits HIF-1α transactivation by recruiting histone deacetylases. Here, we report...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
Oxford University Press
2003
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC154465/ https://ncbi.nlm.nih.gov/pubmed/12682018 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/cdg173 |
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