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Regulation of neddylation and deneddylation of cullin1 in SCF(Skp2) ubiquitin ligase by F-box protein and substrate

The activity of cullin-containing ubiquitin protein ligase complexes is stimulated by linkage to cullin of the ubiquitin-like protein Nedd8 (“neddylation”). Neddylation is inhibited by the tight binding of cullins to CAND1 (cullin-associated and neddylation-dissociated 1) protein, and Nedd8 is remov...

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Autors principals: Bornstein, Gil, Ganoth, Dvora, Hershko, Avram
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2006
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC1544201/
https://ncbi.nlm.nih.gov/pubmed/16861300
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0603921103
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