Structural basis for unique mechanisms of folding and hemoglobin binding by a malarial protease

Falcipain-2 (FP2), the major cysteine protease of the human malaria parasite Plasmodium falciparum, is a hemoglobinase and promising drug target. Here we report the crystal structure of FP2 in complex with a protease inhibitor, cystatin. The FP2 structure reveals two previously undescribed cysteine...

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Detalhes bibliográficos
Main Authors: Wang, Stephanie X., Pandey, Kailash C., Somoza, John R., Sijwali, Puran S., Kortemme, Tanja, Brinen, Linda S., Fletterick, Robert J., Rosenthal, Philip J., McKerrow, James H.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2006
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1544199/
https://ncbi.nlm.nih.gov/pubmed/16864794
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0600489103
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