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Autoreactive T cells can be protected from tolerance induction through competition by flanking determinants for access to class II MHC

It is not clear why the N-terminal autoantigenic determinant of myelin basic protein (MBP), Ac1–9, is dominant in the B1O.PL (H-2(u)) mouse, given its weak I-A(u)-MHC binding affinity. Similarly, how do high-affinity T cells specific for this determinant avoid negative selection? Because the MBP:1–9...

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Dettagli Bibliografici
Autori principali: Maverakis, Emanual, Beech, Jonathan, Stevens, David B., Ametani, Akio, Brossay, Laurent, van den Elzen, Peter, Mendoza, Richard, Thai, Quoc, Macias, Luis H., Ethell, Doug, Campagnoni, Celia W., Campagnoni, Anthony T., Sette, Alessandro, Sercarz, Eli E.
Natura: Artigo
Lingua:Inglês
Pubblicazione: The National Academy of Sciences 2003
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC154347/
https://ncbi.nlm.nih.gov/pubmed/12707414
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0936151100
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