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Autoreactive T cells can be protected from tolerance induction through competition by flanking determinants for access to class II MHC
It is not clear why the N-terminal autoantigenic determinant of myelin basic protein (MBP), Ac1–9, is dominant in the B1O.PL (H-2(u)) mouse, given its weak I-A(u)-MHC binding affinity. Similarly, how do high-affinity T cells specific for this determinant avoid negative selection? Because the MBP:1–9...
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| Autori principali: | , , , , , , , , , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
The National Academy of Sciences
2003
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC154347/ https://ncbi.nlm.nih.gov/pubmed/12707414 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0936151100 |
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