Autoreactive T cells can be protected from tolerance induction through competition by flanking determinants for access to class II MHC

It is not clear why the N-terminal autoantigenic determinant of myelin basic protein (MBP), Ac1–9, is dominant in the B1O.PL (H-2(u)) mouse, given its weak I-A(u)-MHC binding affinity. Similarly, how do high-affinity T cells specific for this determinant avoid negative selection? Because the MBP:1–9...

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Detalhes bibliográficos
Main Authors: Maverakis, Emanual, Beech, Jonathan, Stevens, David B., Ametani, Akio, Brossay, Laurent, van den Elzen, Peter, Mendoza, Richard, Thai, Quoc, Macias, Luis H., Ethell, Doug, Campagnoni, Celia W., Campagnoni, Anthony T., Sette, Alessandro, Sercarz, Eli E.
Formato: Artigo
Idioma:Inglês
Publicado em: The National Academy of Sciences 2003
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC154347/
https://ncbi.nlm.nih.gov/pubmed/12707414
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0936151100
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