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Hot L1s account for the bulk of retrotransposition in the human population

Although LINE-1 (long interspersed nucleotide element-1, L1) retrotransposons comprise 17% of the human genome, an exhaustive search of the December 2001 “freeze” of the haploid human genome working draft sequence (95% complete) yielded only 90 L1s with intact ORFs. We demonstrate that 38 of 86 (44%...

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Udgivet i:Proc Natl Acad Sci U S A
Principais autores: Brouha, Brook, Schustak, Joshua, Badge, Richard M., Lutz-Prigge, Sheila, Farley, Alexander H., Moran, John V., Kazazian, Haig H.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2003
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC154336/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12682288/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.0831042100
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