Use of combinatorial genetic libraries to humanize N-linked glycosylation in the yeast Pichia pastoris

The secretory pathway of Pichia pastoris was genetically re-engineered to perform sequential glycosylation reactions that mimic early processing of N-glycans in humans and other higher mammals. After eliminating nonhuman glycosylation by deleting the initiating α-1,6-mannosyltransferase gene from P....

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Detalles Bibliográficos
Main Authors: Choi, Byung-Kwon, Bobrowicz, Piotr, Davidson, Robert C., Hamilton, Stephen R., Kung, David H., Li, Huijuan, Miele, Robert G., Nett, Juergen H., Wildt, Stefan, Gerngross, Tillman U.
Formato: Artigo
Idioma:Inglês
Publicado: The National Academy of Sciences 2003
Assuntos:
Biological Sciences
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC154291/
https://ncbi.nlm.nih.gov/pubmed/12702754
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0931263100
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