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ATM is a cytoplasmic protein in mouse brain required to prevent lysosomal accumulation

We previously generated a mouse model with a mutation in the murine Atm gene that recapitulates many aspects of the childhood neurodegenerative disease ataxia-telangiectasia. Atm-deficient (Atm−/−) mice show neurological defects detected by motor function tests including the rota-rod, open-field tes...

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Tallennettuna:
Julkaisussa:Proc Natl Acad Sci U S A
Päätekijät: Barlow, Carrolee, Ribaut-Barassin, Catherine, Zwingman, Theresa A., Pope, Amber J., Brown, Kevin D., Owens, Jennie W., Larson, Denise, Harrington, Elizabeth A., Haeberle, Anne-Marie, Mariani, Jean, Eckhaus, Michael, Herrup, Karl, Bailly, Yannick, Wynshaw-Boris, Anthony
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: National Academy of Sciences 2000
Aiheet:
Biological Sciences
Linkit:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC15423/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10639172/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.97.2.871
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