ATM is a cytoplasmic protein in mouse brain required to prevent lysosomal accumulation

We previously generated a mouse model with a mutation in the murine Atm gene that recapitulates many aspects of the childhood neurodegenerative disease ataxia-telangiectasia. Atm-deficient (Atm−/−) mice show neurological defects detected by motor function tests including the rota-rod, open-field tes...

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Detalhes bibliográficos
Main Authors: Barlow, Carrolee, Ribaut-Barassin, Catherine, Zwingman, Theresa A., Pope, Amber J., Brown, Kevin D., Owens, Jennie W., Larson, Denise, Harrington, Elizabeth A., Haeberle, Anne-Marie, Mariani, Jean, Eckhaus, Michael, Herrup, Karl, Bailly, Yannick, Wynshaw-Boris, Anthony
Formato: Artigo
Idioma:Inglês
Publicado em: The National Academy of Sciences 2000
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC15423/
https://ncbi.nlm.nih.gov/pubmed/10639172
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