Attenuation of Mycobacterium tuberculosis by Disruption of a mas-Like Gene or a Chalcone Synthase-Like Gene, Which Causes Deficiency in Dimycocerosyl Phthiocerol Synthesis

Tuberculosis is one of the leading preventable causes of death. Emergence of drug-resistant tuberculosis makes the discovery of new targets for antimycobacterial drugs critical. The unique mycobacterial cell wall lipids are known to play an important role in pathogenesis, and therefore the genes res...

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Hlavní autoři: Sirakova, Tatiana D., Dubey, Vinod S., Cynamon, Michael H., Kolattukudy, Pappachan E.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2003
Témata:
Molecular Biology of Pathogens
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC154080/
https://ncbi.nlm.nih.gov/pubmed/12730158
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JB.185.10.2999-3008.2003
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