In Vivo Evolution of Human Immunodeficiency Virus Type 1 toward Increased Pathogenicity through CXCR4-Mediated Killing of Uninfected CD4 T Cells

The destruction of the immune system by progressive loss of CD4 T cells is the hallmark of AIDS. CCR5-dependent (R5) human immunodeficiency virus type 1 (HIV-1) isolates predominate in the early, asymptomatic stages of HIV-1 infection, while CXCR4-dependent (X4) isolates typically emerge at later st...

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Autores principales: Jekle, Andreas, Keppler, Oliver T., De Clercq, Erik, Schols, Dominique, Weinstein, Mark, Goldsmith, Mark A.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Microbiology 2003
Materias:
Virus-Cell Interactions
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC154038/
https://ncbi.nlm.nih.gov/pubmed/12719578
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.77.10.5846-5854.2003
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