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Modest Human Immunodeficiency Virus Coreceptor Function of CXCR3 Is Strongly Enhanced by Mimicking the CXCR4 Ligand Binding Pocket in the CXCR3 Receptor

The chemokine receptor CXCR3 can exhibit weak coreceptor function for several human immunodeficiency virus type 1 (HIV-1) and HIV-2 strains and clinical isolates. These viruses produced microscopically visible cytopathicity in U87.CD4.CXCR3 cell cultures, whereas untransfected (CXCR3-negative) U87.C...

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Bibliografische gegevens
Hoofdauteurs: Hatse, Sigrid, Huskens, Dana, Princen, Katrien, Vermeire, Kurt, Bridger, Gary J., De Clercq, Erik, Rosenkilde, Mette M., Schwartz, Thue W., Schols, Dominique
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Society for Microbiology 2007
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1866035/
https://ncbi.nlm.nih.gov/pubmed/17251291
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01941-06
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