Modest Human Immunodeficiency Virus Coreceptor Function of CXCR3 Is Strongly Enhanced by Mimicking the CXCR4 Ligand Binding Pocket in the CXCR3 Receptor

The chemokine receptor CXCR3 can exhibit weak coreceptor function for several human immunodeficiency virus type 1 (HIV-1) and HIV-2 strains and clinical isolates. These viruses produced microscopically visible cytopathicity in U87.CD4.CXCR3 cell cultures, whereas untransfected (CXCR3-negative) U87.C...

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Bibliografiske detaljer
Main Authors: Hatse, Sigrid, Huskens, Dana, Princen, Katrien, Vermeire, Kurt, Bridger, Gary J., De Clercq, Erik, Rosenkilde, Mette M., Schwartz, Thue W., Schols, Dominique
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2007
Fag:
Virus-Cell Interactions
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1866035/
https://ncbi.nlm.nih.gov/pubmed/17251291
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01941-06
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