Modest Human Immunodeficiency Virus Coreceptor Function of CXCR3 Is Strongly Enhanced by Mimicking the CXCR4 Ligand Binding Pocket in the CXCR3 Receptor

The chemokine receptor CXCR3 can exhibit weak coreceptor function for several human immunodeficiency virus type 1 (HIV-1) and HIV-2 strains and clinical isolates. These viruses produced microscopically visible cytopathicity in U87.CD4.CXCR3 cell cultures, whereas untransfected (CXCR3-negative) U87.C...

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Autores principales: Hatse, Sigrid, Huskens, Dana, Princen, Katrien, Vermeire, Kurt, Bridger, Gary J., De Clercq, Erik, Rosenkilde, Mette M., Schwartz, Thue W., Schols, Dominique
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Microbiology 2007
Materias:
Virus-Cell Interactions
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC1866035/
https://ncbi.nlm.nih.gov/pubmed/17251291
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01941-06
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