Amphipathic Helix-Dependent Localization of NS5A Mediates Hepatitis C Virus RNA Replication

We identified an N-terminal amphipathic helix (AH) in one of hepatitis C virus (HCV)’s nonstructural proteins, NS5A. This AH is necessary and sufficient for membrane localization and is conserved across isolates. Genetically disrupting the AH impairs HCV replication. Moreover, an AH peptide-mimic in...

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Main Authors: Elazar, Menashe, Cheong, Kwang Ho, Liu, Ping, Greenberg, Harry B., Rice, Charles M., Glenn, Jeffrey S.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Microbiology 2003
Assuntos:
Replication
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC154017/
https://ncbi.nlm.nih.gov/pubmed/12719597
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.77.10.6055-6061.2003
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