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Binding Dynamics of Hepatitis C Virus' NS5A Amphipathic Peptide to Cell and Model Membranes

Membrane association of the hepatitis C virus NS5A protein is required for viral replication. This association is dependent on an N-terminal amphipathic helix (AH) within NS5A and is restricted to a subset of host cell intracellular membranes. The mechanism underlying this specificity is not known,...

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Detalhes bibliográficos
Main Authors: Cho, Nam-Joon, Cheong, Kwang Ho, Lee, ChoongHo, Frank, Curtis W., Glenn, Jeffrey S.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2007
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1900085/
https://ncbi.nlm.nih.gov/pubmed/17428867
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02783-06
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