Molecular Features of the Broadly Neutralizing Immunoglobulin G1 b12 Required for Recognition of Human Immunodeficiency Virus Type 1 gp120

IgG1 b12 is a broadly neutralizing antibody against human immunodeficiency virus type 1 (HIV-1). The epitope recognized by b12 overlaps the CD4 receptor-binding site (CD4bs) on gp120 and has been a target for vaccine design. Determination of the three-dimensional structure of immunoglobulin G1 (IgG1...

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Autores principales: Zwick, Michael B., Parren, Paul W. H. I., Saphire, Erica O., Church, Sarah, Wang, Meng, Scott, Jamie K., Dawson, Philip E., Wilson, Ian A., Burton, Dennis R.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Microbiology 2003
Materias:
Pathogenesis and Immunity
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC154005/
https://ncbi.nlm.nih.gov/pubmed/12719580
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.77.10.5863-5876.2003
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