Inhibition of Plasmodium falciparum Growth In Vitro and Adhesion to Chondroitin-4-Sulfate by the Heparan Sulfate Mimetic PI-88 and Other Sulfated Oligosaccharides

A panel of sulfated oligosaccharides was tested for antimalarial activity and inhibition of adhesion to the placental malaria receptor chondroitin-4-sulfate (CSA). The heparan sulfate mimetic PI-88, currently undergoing phase II anticancer trials, displayed the greatest in vitro antimalarial activit...

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Detalhes bibliográficos
Main Authors: Adams, Yvonne, Freeman, Craig, Schwartz-Albiez, Reinhard, Ferro, Vito, Parish, Christopher R., Andrews, Katherine T.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2006
Assuntos:
Susceptibility
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1538674/
https://ncbi.nlm.nih.gov/pubmed/16870784
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00313-06
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