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Cytokine signals modulated via lipid rafts mimic niche signals and induce hibernation in hematopoietic stem cells

Hematopoietic stem cells (HSCs) reside in the bone marrow (BM) niche in a noncycling state and enter the cell cycle at long intervals. However, little is known about inter- and intracellular signaling mechanisms underlying this unique property of HSCs. Here, we show that lipid raft clustering is a k...

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Detalhes bibliográficos
Main Authors: Yamazaki, Satoshi, Iwama, Atsushi, Takayanagi, Shin-ichiro, Morita, Yohei, Eto, Koji, Ema, Hideo, Nakauchi, Hiromitsu
Formato: Artigo
Idioma:Inglês
Publicado em: 2006
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1538571/
https://ncbi.nlm.nih.gov/pubmed/16858398
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7601236
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