Age-Associated Characteristics of Murine Hematopoietic Stem Cells

Little is known of age-associated functional changes in hematopoietic stem cells (HSCs). We studied aging HSCs at the clonal level by isolating CD34(−/low)c-Kit(+)Sca-1(+) lineage marker–negative (CD34(−)KSL) cells from the bone marrow of C57BL/6 mice. A population of CD34(−)KSL cells gradually expa...

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Bibliographic Details
Main Authors: Sudo, Kazuhiro, Ema, Hideo, Morita, Yohei, Nakauchi, Hiromitsu
Format: Artigo
Language:Inglês
Published: The Rockefeller University Press 2000
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Original Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2193349/
https://ncbi.nlm.nih.gov/pubmed/11067876
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