Endogenous phosphatidylcholine and a long spacer ligand stabilize the lipid-binding groove of CD1b

CD1 proteins present lipid antigens to T cells. The antigens are acquired in the endosomal compartments. This raises the question of how the large hydrophobic CD1 pockets are preserved between the moment of biosynthesis in the endoplasmic reticulum and arrival to the endosomes. To address this issue...

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Bibliographic Details
Main Authors: Garcia-Alles, Luis F, Versluis, Kees, Maveyraud, Laurent, Vallina, Ana Tesouro, Sansano, Sebastiano, Bello, Nana Fatimath, Gober, Hans-Jürgen, Guillet, Valérie, de la Salle, Henri, Puzo, Germain, Mori, Lucia, Heck, Albert J R, De Libero, Gennaro, Mourey, Lionel
Format: Artigo
Language:Inglês
Published: 2006
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1538567/
https://ncbi.nlm.nih.gov/pubmed/16874306
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7601244
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