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Endogenous phosphatidylcholine and a long spacer ligand stabilize the lipid-binding groove of CD1b

CD1 proteins present lipid antigens to T cells. The antigens are acquired in the endosomal compartments. This raises the question of how the large hydrophobic CD1 pockets are preserved between the moment of biosynthesis in the endoplasmic reticulum and arrival to the endosomes. To address this issue...

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Autors principals: Garcia-Alles, Luis F, Versluis, Kees, Maveyraud, Laurent, Vallina, Ana Tesouro, Sansano, Sebastiano, Bello, Nana Fatimath, Gober, Hans-Jürgen, Guillet, Valérie, de la Salle, Henri, Puzo, Germain, Mori, Lucia, Heck, Albert J R, De Libero, Gennaro, Mourey, Lionel
Format: Artigo
Idioma:Inglês
Publicat: 2006
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC1538567/
https://ncbi.nlm.nih.gov/pubmed/16874306
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7601244
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