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Genome-wide replication profiles of S-phase checkpoint mutants reveal fragile sites in yeast
The S-phase checkpoint kinases Mec1 and Rad53 in the budding yeast, Saccharomyces cerevisiae, are activated in response to replication stress that induces replication fork arrest. In the absence of a functional S-phase checkpoint, stalled replication forks collapse and give rise to chromosome breaka...
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| Autori principali: | , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2006
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1538557/ https://ncbi.nlm.nih.gov/pubmed/16888628 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7601251 |
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