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Active Replication Checkpoint Drives Genome Instability in Fission Yeast mcm4 Mutant
Upon replication fork arrest, the replication checkpoint kinase Cds1 is stimulated to preserve genome integrity. Robust activation of Cds1 in response to hydroxyurea prevents the endonuclease Mus81 from cleaving the stalled replication fork inappropriately. However, we find that the response is diff...
Shranjeno v:
| izdano v: | Mol Cell Biol |
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| Main Authors: | , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
American Society for Microbiology
2020
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7324846/ https://ncbi.nlm.nih.gov/pubmed/32341083 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00033-20 |
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