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Active Replication Checkpoint Drives Genome Instability in Fission Yeast mcm4 Mutant
Upon replication fork arrest, the replication checkpoint kinase Cds1 is stimulated to preserve genome integrity. Robust activation of Cds1 in response to hydroxyurea prevents the endonuclease Mus81 from cleaving the stalled replication fork inappropriately. However, we find that the response is diff...
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| Gepubliceerd in: | Mol Cell Biol |
|---|---|
| Hoofdauteurs: | , |
| Formaat: | Artigo |
| Taal: | Inglês |
| Gepubliceerd in: |
American Society for Microbiology
2020
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| Onderwerpen: | |
| Online toegang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7324846/ https://ncbi.nlm.nih.gov/pubmed/32341083 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00033-20 |
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