Evidence that the retroviral DNA integration process triggers an ATR-dependent DNA damage response

Caffeine is an efficient inhibitor of cellular DNA repair, likely through its effects on ATM (ataxia telangiectasia mutated) and ATR (ATM and Rad3-related) kinases. Here, we show that caffeine treatment causes a dose-dependent reduction in the total amount of HIV-1 and avian sarcoma virus retroviral...

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Veröffentlicht in:	Proc Natl Acad Sci U S A
Hauptverfasser:	Daniel, René, Kao, Gary, Taganov, Konstantin, Greger, James G., Favorova, Olga, Merkel, George, Yen, Tim J., Katz, Richard A., Skalka, Anna Marie
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	National Academy of Sciences 2003
Schlagworte:	Biological Sciences
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC153632/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12679521/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.0730887100
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