Treatment with isotretinoin inhibits lipofuscin accumulation in a mouse model of recessive Stargardt's macular degeneration

Recessive Stargardt's macular degeneration is an inherited blinding disease of children caused by mutations in the ABCR gene. The primary pathologic defect in Stargardt's disease is accumulation of toxic lipofuscin pigments such as N-retinylidene-N-retinylethanolamine (A2E) in cells of the...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Radu, Roxana A., Mata, Nathan L., Nusinowitz, Steven, Liu, Xinran, Sieving, Paul A., Travis, Gabriel H.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: The National Academy of Sciences 2003
Pynciau:
Biological Sciences
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC153626/
https://ncbi.nlm.nih.gov/pubmed/12671074
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0737855100
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