Treatment with isotretinoin inhibits lipofuscin accumulation in a mouse model of recessive Stargardt's macular degeneration

Recessive Stargardt's macular degeneration is an inherited blinding disease of children caused by mutations in the ABCR gene. The primary pathologic defect in Stargardt's disease is accumulation of toxic lipofuscin pigments such as N-retinylidene-N-retinylethanolamine (A2E) in cells of the...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: Radu, Roxana A., Mata, Nathan L., Nusinowitz, Steven, Liu, Xinran, Sieving, Paul A., Travis, Gabriel H.
Formato: Artigo
Lenguaje:Inglês
Publicado: The National Academy of Sciences 2003
Materias:
Biological Sciences
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC153626/
https://ncbi.nlm.nih.gov/pubmed/12671074
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0737855100
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!

Ejemplares similares