Identification of a small molecule inhibitor of the hedgehog signaling pathway: Effects on basal cell carcinoma-like lesions

The link between basal cell carcinoma (BCC) and aberrant activation of the Hedgehog (Hh) signaling pathway has been well established in humans and in mouse models. Here we report the development of assays, including two novel in vitro BCC models, which allowed us to screen for Hh inhibitors and test...

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Detalhes bibliográficos
Main Authors: Williams, Juliet A., Guicherit, Oivin M., Zaharian, Beatrice I., Xu, Yin, Chai, Ling, Wichterle, Hynek, Kon, Charlene, Gatchalian, Christine, Porter, Jeffery A., Rubin, Lee L., Wang, Frank Y.
Formato: Artigo
Idioma:Inglês
Publicado em: The National Academy of Sciences 2003
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC153604/
https://ncbi.nlm.nih.gov/pubmed/12679522
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0732813100
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