Identification of a small molecule inhibitor of the hedgehog signaling pathway: Effects on basal cell carcinoma-like lesions

The link between basal cell carcinoma (BCC) and aberrant activation of the Hedgehog (Hh) signaling pathway has been well established in humans and in mouse models. Here we report the development of assays, including two novel in vitro BCC models, which allowed us to screen for Hh inhibitors and test...

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Autori principali: Williams, Juliet A., Guicherit, Oivin M., Zaharian, Beatrice I., Xu, Yin, Chai, Ling, Wichterle, Hynek, Kon, Charlene, Gatchalian, Christine, Porter, Jeffery A., Rubin, Lee L., Wang, Frank Y.
Natura: Artigo
Lingua:Inglês
Pubblicazione: The National Academy of Sciences 2003
Soggetti:
Biological Sciences
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC153604/
https://ncbi.nlm.nih.gov/pubmed/12679522
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0732813100
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