Phosphorylation of p47(phox) directs phox homology domain from SH3 domain toward phosphoinositides, leading to phagocyte NADPH oxidase activation

Protein–phosphoinositide interaction participates in targeting proteins to membranes where they function correctly and is often modulated by phosphorylation of lipids. Here we show that protein phosphorylation of p47(phox), a cytoplasmic activator of the microbicidal phagocyte oxidase (phox), elicit...

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Bibliographic Details
Main Authors: Ago, Tetsuro, Kuribayashi, Futoshi, Hiroaki, Hidekazu, Takeya, Ryu, Ito, Takashi, Kohda, Daisuke, Sumimoto, Hideki
Format: Artigo
Language:Inglês
Published: The National Academy of Sciences 2003
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC153580/
https://ncbi.nlm.nih.gov/pubmed/12672956
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0735712100
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