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Phosphorylation of p47(phox) directs phox homology domain from SH3 domain toward phosphoinositides, leading to phagocyte NADPH oxidase activation

Protein–phosphoinositide interaction participates in targeting proteins to membranes where they function correctly and is often modulated by phosphorylation of lipids. Here we show that protein phosphorylation of p47(phox), a cytoplasmic activator of the microbicidal phagocyte oxidase (phox), elicit...

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Udgivet i:Proc Natl Acad Sci U S A
Principais autores: Ago, Tetsuro, Kuribayashi, Futoshi, Hiroaki, Hidekazu, Takeya, Ryu, Ito, Takashi, Kohda, Daisuke, Sumimoto, Hideki
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2003
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC153580/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12672956/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.0735712100
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