High-fidelity in vivo replication of DNA base shape mimics without Watson–Crick hydrogen bonds

We report studies testing the importance of Watson–Crick hydrogen bonding, base-pair geometry, and steric effects during DNA replication in living bacterial cells. Nonpolar DNA base shape mimics of thymine and adenine (abbreviated F and Q, respectively) were introduced into Escherichia coli by inser...

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Detalles Bibliográficos
Autores principales: Delaney, James C., Henderson, Paul T., Helquist, Sandra A., Morales, Juan C., Essigmann, John M., Kool, Eric T.
Formato: Artigo
Lenguaje:Inglês
Publicado: The National Academy of Sciences 2003
Materias:
Biological Sciences
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC153579/
https://ncbi.nlm.nih.gov/pubmed/12676985
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0837277100
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