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In-frame deletion in the EGF receptor alters kinase inhibition by gefitinib
The existence of an in-frame deletion mutant correlates with the sensitivity of lung cancers to EGFR (epidermal growth factor receptor)-targeted tyrosine kinase inhibitors. We reported previously that the in-frame 15-bp deletional mutation (delE746–A750 type deletion) was constitutively active in ce...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Portland Press Ltd.
2006
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1533307/ https://ncbi.nlm.nih.gov/pubmed/16623663 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20051962 |
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