In-frame deletion in the EGF receptor alters kinase inhibition by gefitinib

The existence of an in-frame deletion mutant correlates with the sensitivity of lung cancers to EGFR (epidermal growth factor receptor)-targeted tyrosine kinase inhibitors. We reported previously that the in-frame 15-bp deletional mutation (delE746–A750 type deletion) was constitutively active in ce...

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Autores principales: Sakai, Kazuko, Yokote, Hideyuki, Murakami-Murofushi, Kimiko, Tamura, Tomohide, Saijo, Nagahiro, Nishio, Kazuto
Formato: Artigo
Lenguaje:Inglês
Publicado: Portland Press Ltd. 2006
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC1533307/
https://ncbi.nlm.nih.gov/pubmed/16623663
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20051962
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