Long CTG Tracts from the Myotonic Dystrophy Gene Induce Deletions and Rearrangements during Recombination at the APRT Locus in CHO Cells

Expansion of CTG triplet repeats in the 3′ untranslated region of the DMPK gene causes the autosomal dominant disorder myotonic dystrophy. Instability of CTG repeats is thought to arise from their capacity to form hairpin DNA structures. How these structures interact with various aspects of DNA meta...

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Autores principales: Meservy, James L., Sargent, R. Geoffrey, Iyer, Ravi R., Chan, Fung, McKenzie, Gregory J., Wells, Robert D., Wilson, John H.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Microbiology 2003
Materias:
DNA Dynamics and Chromosome Structure
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC153196/
https://ncbi.nlm.nih.gov/pubmed/12697816
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.23.9.3152-3162.2003
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