Long CTG Tracts from the Myotonic Dystrophy Gene Induce Deletions and Rearrangements during Recombination at the APRT Locus in CHO Cells

Expansion of CTG triplet repeats in the 3′ untranslated region of the DMPK gene causes the autosomal dominant disorder myotonic dystrophy. Instability of CTG repeats is thought to arise from their capacity to form hairpin DNA structures. How these structures interact with various aspects of DNA meta...

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Bibliografiske detaljer
Main Authors: Meservy, James L., Sargent, R. Geoffrey, Iyer, Ravi R., Chan, Fung, McKenzie, Gregory J., Wells, Robert D., Wilson, John H.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2003
Fag:
DNA Dynamics and Chromosome Structure
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC153196/
https://ncbi.nlm.nih.gov/pubmed/12697816
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.23.9.3152-3162.2003
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